Compound name
Vps34-IN-1
Protein family
lipid-kinase
Target name
PIK3C3
Affinity biochemical (nM)
25
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000631a
SMILES
OC(C)(C)CNC1=NC(CC2CC2)=C(C3=CC=NC(NC4=CC=NC(Cl)=C4)=N3)C=N1
InChIKey
AWNXKZVIZARMME-UHFFFAOYSA-N
NCBI gene ID
5289
UniProt ID
Q8NEB9
Synonyms
Vps34
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radioactive liposome kinase assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1042/BJ20140889
Affinity biochemical relation
=
Selectivity platform
Kinase panel (ProQinase)
Selectivity platform number of targets
300
Selectivity remarks
Screened at 1 µM, >1000-fold selective against other targets; Screened in Dundee panel against 140 kinases and 19 lipid kinases at 1 µM, >1000-fold selective; Screened in AstraZeneca panel against 8 lipid kinases, closest target: IC50(PIP5K1C) = 382 µM, IC50(PI4K3B) = 1.069 µM, IC50(PI3Kd) = 1.896 µM, others >2 µM; Screened in ProQuinase panel against 13 lipid kinases at 1 µM, closest targets: IC50(PIP5K1A) = 4.93 µM, IC50(PIP5K1C) = 3.37 µM;
Selectivity Source Knowledge
https://doi.org/10.1042/BJ20140889
Selectivity Number of Off-targets
0