Compound name
JNJ-47117096
Protein family
Protein Kinase
Target name
FLT3
Affinity biochemical (nM)
18
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001485a
SMILES
COc1cc(-c2cn[nH]c2)ccc1C(=O)Nc1ccc2c(c1)CCNCC2.Cl
InChIKey
OXRWZUUCCUDKJJ-UHFFFAOYSA-N
NCBI gene ID
2322
UniProt ID
P36888
Synonyms
STK1, FLK2, CD135
Mode of action
inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radioactive filter binding assay (10 µM ATP)
Affinity Biochemical Source Knowledge
https://pubs.acs.org/doi/10.1021/ml5001245
Affinity biochemical relation
=
Selectivity platform
KinaseProfile service (Milipore)
Selectivity platform number of targets
235
Selectivity remarks
Screened at 1 µM, closest targets as % of contr.: CAMK2D (60%), CAMK2G (59%), MKNK2 (55%), MYLK (54%); In-vitro follow-up (enzymatic assays, Milipore): IC50(CAMK2D) = 810 nM, IC50(MKNK2) = 760 nM, IC50(CAMK2G) = 1000 nM, IC50(MYLK) = 1000 nM;
Selectivity Source Knowledge
https://pubs.acs.org/doi/10.1021/ml5001245