Compound name
CS640s
Protein family
Protein Kinase
Target name
CAMK1D
Affinity biochemical (nM)
1.71
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0002216a
SMILES
CNC(=O)c1cnc(N2CCC[C@H](N)C2)nc1Nc1cc(C(C)C)nc(C(C)C)c1
InChIKey
BULCCNLYFBCNHQ-HNNXBMFYSA-N
NCBI gene ID
57118
UniProt ID
Q8IU85
Synonyms
CKLiK
Mode of action
Negative control for CS640
Affinity biochemical definition
dTm
Affinity biochemical assay type
DSF assay
Affinity Biochemical Source Knowledge
https://www.thesgc.org/chemical-probes/cs-640
Affinity biochemical relation
0
Selectivity platform
Kinase panel (DSF assay)
Selectivity platform number of targets
100
Selectivity remarks
Screened at 20 µM, closest targets as shift in temperature: dTm(DCAMKL1) = 1.69 K, dTm(DMPK1) = 1.16 K, dTm(EPHA7) = 1.33 K, dTm(CAMK1D) = 1.71 K, dTm(CAMK1G) = 2.02 K, dTm(TIF1) = 2.74 K, dTm(TLK1) = 1.18K
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/cs-640
Selectivity Number of Off-targets
0