Compound name
AR-A014418
Protein family
Protein Kinase
Target name
GSK3B
Affinity biochemical (nM)
0.116
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002897a
SMILES
O=C(NCC1=CC=C(OC)C=C1)NC2=NC=C([N+]([O-])=O)S2
InChIKey
YAEMHJKFIIIULI-UHFFFAOYSA-N
NCBI gene ID
2932
UniProt ID
P49841
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Mobility shift microfluidic assay (Caliper, MA)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/27128528/
Affinity biochemical relation
=
Selectivity platform
KINOMEscan (DiscoveRx)
Selectivity platform number of targets
402
Selectivity remarks
Screened at 10 µM, closest targets as % of control: MST2 (3.4%), KIT(V5559D, 3.6%), PCTK1 (15%), RIOK2 (23%), STK16 (28%), YSK4 (49%), HIPK4 (49%), GSK3A (0.1%), GSK3B (11%), PRKX (42%), full screening data available as supporting information;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/27128528/
Selectivity Number of Off-targets
2