1. Chemogenomics
2. BRAF

BRAF

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

673

1097

P15056

BRAF_HUMAN

Serine/threonine-protein kinase B-raf

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000135b

GDC-0879

OCCn1cc(-c2ccc3c(c2)CCC3=NO)c(-c2ccncc2)n1

DEZZLWQELQORIU-UHFFFAOYSA-N

BRAF

Yes

Yes

No

No

EUB0000597a

PLX-4720

O=C(C1=C(F)C(NS(CCC)(=O)=O)=CC=C1F)C2=CNC3=NC=C(Cl)C=C32

YZDJQTHVDDOVHR-UHFFFAOYSA-N

BRAF

Yes

Yes

No

No

EUB0000655a

SB-590885

CN(C)CCOC1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C(/C(CC5)=N/O)C5=C4)N2)C=C1

MLSAQOINCGAULQ-QFMPWRQOSA-N

BRAF

,

RAF1

Yes

Yes

No

No