1. Chemogenomics
  2. CDK4

CDK4

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family
1019
1773
P11802
CDK4_HUMAN
Cyclin-dependent kinase 4
Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available
EUB0000588a
CINK4
Chemical structure of compound CINK4
CCNC1=CC(=NC(=N1)NC2=CC3=C(C=C2)N(C=C3)CC4=CC=CC=C4)NC5CCC(CC5)O
YVXCDLCJCIDFHE-AFARHQOCSA-N
CDK4
,
CDK6
No
Yes
No
Yes
EUB0000686a
Ribociclib
Chemical structure of compound Ribociclib
O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(C=C4)=NC=C4N5CCNCC5
RHXHGRAEPCAFML-UHFFFAOYSA-N
CDK4
,
CDK6
Yes
Yes
No
Yes
EUB0000692aMSA
Abemaciclib (methanesulfonate)
Chemical structure of compound Abemaciclib (methanesulfonate)
CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
NCJPFQPEVDHJAZ-UHFFFAOYSA-N
CDK4
,
CDK6
Yes
Yes
Yes
Yes