1. Chemogenomics
2. NR3C1

NR3C1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

2908

7978

P04150

GCR_HUMAN

glucocorticoid receptor

Nuclear receptor

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000314b

BI-653048

CCS(=O)(=O)c1cc2cc(C[C@](O)(CC(C)(C)c3ccc(F)cc3C(N)=O)C(F)(F)F)[nH]c2cn1

AUIFRJWXYUNPPV-QFIPXVFZSA-N

agonist

NR3C1

No

Yes

No

Yes

EUB0000558a

fluticasone propionate

CCC(=O)O[C@@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C)C(=O)SCF

WMWTYOKRWGGJOA-CENSZEJFSA-N

NR3C1

,

PGR

Yes

Yes

Yes

Yes

EUB0000559a

beclomethasone

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)Cl)C

NBMKJKDGKREAPL-DVTGEIKXSA-N

NR3C1

Yes

Yes

No

Yes

EUB0000586a

BI-3047

CCS(C1=NC=C2NC(C[C@@](O)(CC(C3=CC=C(C=C3C(N)=O)F)(C)C)C(F)(F)F)=CC2=C1)(=O)=O

AUIFRJWXYUNPPV-JOCHJYFZSA-N

Neg Ctrl (BI-653048)

NR3C1

Yes

Yes

No

Yes