1. Chemogenomics
2. PAK1

PAK1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

5058

8590

Q13153

PAK1_HUMAN

Serine/threonine-protein kinase PAK 1

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000117b

FRAX486

CCn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2cnc(Nc3ccc(N4CCNCC4)c(F)c3)nc21

DHKFOIHIUYFSOF-UHFFFAOYSA-N

PAK1

,

PAK2

,

PAK3

Yes

Yes

Yes

Yes

EUB0000164c

NVS-PAK1-1

CC(C)NC(=O)N1CC[C@H](NC2=Nc3cc(F)ccc3N(CC(F)F)c3ccc(Cl)cc32)C1

OINGHOPGNMYCAB-INIZCTEOSA-N

PAK1

Yes

Yes

Yes

Yes

EUB0000625a

FRAX597

CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=CN=CS4)Cl)NC5=CC=C(C=C5)N6CCN(CC6)C

DHUJCQOUWQMVCG-UHFFFAOYSA-N

PAK1

,

PAK2

,

PAK3

No

Yes

Yes

Yes