1. Chemogenomics
2. PTK2

PTK2

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

5747

9611

Q05397

FAK1_HUMAN

Focal adhesion kinase 1

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000138b

Defacitinib

O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(C)(=O)=O)=N2)C=C1

FWLMVFUGMHIOAA-UHFFFAOYSA-N

PTK2

,

PTK2B

Yes

Yes

No

Yes

EUB0000138c

PF-04554878

CNC(C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=C(N(S(C)(=O)=O)C)N=CC=N3)=N2)C=C1)=O

FWLMVFUGMHIOAA-UHFFFAOYSA-N

PTK2

,

PTK2B

Yes

Yes

No

Yes

EUB0000141b

PND-1186

CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2OC)ncc1C(F)(F)F

IGUBBWJDMLCRIK-UHFFFAOYSA-N

PTK2

Yes

Yes

No

Yes

EUB0000668a

PF-431396

CN(S(C)(=O)=O)C1=C(CNC2=C(C(F)(F)F)C=NC(NC3=CC=C(NC(C4)=O)C4=C3)=N2)C=CC=C1

POJZIZBONPAWIV-UHFFFAOYSA-N

PTK2

,

PTK2B

Yes

Yes

No

Yes

EUB0000702a

PF-00911705

CN(S(C)(=O)=O)C1=CC=NC(CNC2=C(C(F)(F)F)C=NC(NC3=CC(CC(N4)=O)=C4C=C3)=N2)=N1

BJRRXLJCIAUKMM-UHFFFAOYSA-N

Neg Ctrl (PF-04554878)

PTK2

,

PTK2B

Yes

Yes

No

Yes