1. Chemogenomics
2. S1PR1

S1PR1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

1901

3165

P21453

S1PR1_HUMAN

sphingosine-1-phosphate receptor 1

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000441a

SEW 2871

FC(F)(F)C1=C(C=C(S1)C1=NC(=NO1)C1=CC(=CC=C1)C(F)(F)F)C1=CC=CC=C1

OYMNPJXKQVTQTR-UHFFFAOYSA-N

Agonist

S1PR1

Yes

Yes

No

Yes

EUB0000501a

NIBR0213

C[C@H](NC(=O)C1=C(C)C=C(C=C1C)C1=CC(N[C@H](C)C2=CC(C)=C(Cl)C=C2)=CC=C1)C(O)=O

KYHUARFFBDLROH-MOPGFXCFSA-N

Antagonist

S1PR1

Yes

Yes

No

Yes

EUB0000516a

TC-SP 14

OC(=O)C1CN(CC2=CC=C(C3=NC4=CC(CC5=CC=CC=C5F)=CC=C4S3)C(F)=C2)C1

GVXGVDIXINMAAL-UHFFFAOYSA-N

Agonist

S1PR1

Yes

Yes

No

Yes

EUB0000522a

ETRASIMOD

OC(=O)C[C@H]1CCC2=C1NC1=CC=C(OCC3=CC=C(C4CCCC4)C(=C3)C(F)(F)F)C=C21

MVGWUTBTXDYMND-QGZVFWFLSA-N

Agonist

S1PR1

,

S1PR5

Yes

Yes

No

Yes