1. Chemogenomics
2. AKT1

AKT1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

207

391

P31749

AKT1_HUMAN

RAC-alpha serine/threonine-protein kinase

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000130bCl

MK-2206 2HCl

Cl.Cl.NC1(c2ccc(-c3nc4ccn5c(=O)[nH]nc5c4cc3-c3ccccc3)cc2)CCC1

HWUHTJIKQZZBRA-UHFFFAOYSA-N

allosteric

AKT1

,

AKT2

,

AKT3

Yes

Yes

No

Yes

EUB0000637a

BAY1125976

C1CC(C1)(C2=CC=C(C=C2)C3=C(N4C(=N3)C=CC(=N4)C(=O)N)C5=CC=CC=C5)N

JBGYKRAZYDNCNV-UHFFFAOYSA-N

allosteric

AKT1

,

AKT2

Yes

Yes

No

Yes

EUB0000645a

Borussertib

C=CC(=O)Nc1ccc2[nH]c(=O)n(C3CCN(Cc4ccc(-c5nc6cc[nH]c(=O)c6cc5-c5ccccc5)cc4)CC3)c2c1

HXBRBOYWXDLHDC-UHFFFAOYSA-N

AKT1

,

AKT2

Yes

Yes

No

Yes

EUB0000653a

AKT inhibitor VIII

C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=C(N=C6C=C7C(=NC=N7)C=C6N5)C8=CC=CC=C8

IWCQHVUQEFDRIW-UHFFFAOYSA-N

allosteric

AKT1

,

AKT2

Yes

Yes

No

Yes

EUB0000721a

RL2841

C=CC(=O)Nc1ccc2[nH]c(=O)n(C3CCN(C(=O)c4ccc(-c5nc6cc[nH]c(=O)c6cc5-c5ccccc5)cc4)CC3)c2c1

DOWXJKCQWFHDRU-UHFFFAOYSA-N

Neg Ctrl (borussertib)

AKT1

,

AKT2

,

AKT3

Yes

Yes

No

No