1. Chemogenomics
2. AKT3

AKT3

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

10000

393

Q9Y243

AKT3_HUMAN

RAC-gamma serine/threonine-protein kinase

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000130bCl

MK-2206 2HCl

Cl.Cl.NC1(c2ccc(-c3nc4ccn5c(=O)[nH]nc5c4cc3-c3ccccc3)cc2)CCC1

HWUHTJIKQZZBRA-UHFFFAOYSA-N

allosteric

AKT1

,

AKT2

,

AKT3

Yes

Yes

No

Yes

EUB0000721a

RL2841

C=CC(=O)Nc1ccc2[nH]c(=O)n(C3CCN(C(=O)c4ccc(-c5nc6cc[nH]c(=O)c6cc5-c5ccccc5)cc4)CC3)c2c1

DOWXJKCQWFHDRU-UHFFFAOYSA-N

Neg Ctrl (borussertib)

AKT1

,

AKT2

,

AKT3

Yes

Yes

No

No