1. Chemogenomics
2. CHRM1

CHRM1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

1128

1950

P11229

ACM1_HUMAN

cholinergic receptor muscarinic 1

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000252b

MSD-M1PAM

N#CC1(c2ccccn2)CCN(Cc2cc(C(=O)O)c(=O)n3ccccc23)CC1

RJTJRVASUFIDQM-UHFFFAOYSA-N

CHRM1

Yes

Yes

No

Yes

EUB0000344a

MSD-M1PAM-NC

N#CC(CC1)(C2=CC=CC=N2)CCN1CC3=C4C=CC=CN4C(C(C(N5CCCC5)=O)=C3)=O

ASAKPTPDFNXOQN-UHFFFAOYSA-N

Neg Ctrl (MSD-M1PAM)

CHRM1

Yes

Yes

No

Yes

EUB0000369a

AQ-RA 741

CCN(CC)CCCCC1CCN(CC(=O)N2C3=C(C=CC=C3)C(=O)NC3=C2N=CC=C3)CC1

BCUGCHZRMKTPMU-UHFFFAOYSA-N

Antagonist

CHRM1

,

CHRM2

,

CHRM3

,

CHRM4

Yes

Yes

No

Yes

EUB0000443aCl

DIFLUOROBENZTROPINE

CN1C2CCC1CC(C2)OC(C1=CC=C(F)C=C1)C1=CC=C(F)C=C1

YOORVSGDAHWVMC-UHFFFAOYSA-N

Antagonist

CHRM1

,

DRD3

Yes

Yes

Yes

Yes