1. Chemogenomics
2. DRD4

DRD4

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

1815

3025

P21917

DRD4_HUMAN

dopamine receptor D4

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000290bCl

ABT-724

C(N1CCN(CC1)C1=NC=CC=C1)C1=NC2=CC=CC=C2N1

AZFUVPBLKQGSRI-UHFFFAOYSA-N

Partial agonist

DRD4

Yes

Yes

No

Yes

EUB0000332a

A-769

CSc1ccncc1N2CCN(Cc3nc4ccccc4[nH]3)CC2

MGBNTFOCYSALPQ-UHFFFAOYSA-N

Neg Ctrl (ABT-724)

DRD4

Yes

Yes

No

No

EUB0000338a

UCSF924NC

CC1=CC(C(C=C(N2)CNCCCC3=CC=NC=C3)=O)=C2C=C1

PALPPRFQCFXPCD-UHFFFAOYSA-N

Neg Ctrl (UCSF924)

DRD4

Yes

Yes

No

Yes

EUB0000366a

FANANSERIN

FC1=CC=C(C=C1)N1CCN(CCCN2C3=C4C(=CC=CC4=CC=C3)S2(=O)=O)CC1

VGIGHGMPMUCLIQ-UHFFFAOYSA-N

Antagonist

DRD4

,

HTR2A

,

HTR2C

Yes

Yes

No

Yes

EUB0000539a

UCSF924

Cc1ccc2c(c1)C(=O)CC(CNCCCOc1ccccc1)N2

RPHDOVLXDYWDGF-UHFFFAOYSA-N

DRD4

Yes

Yes

No

Yes