1. Chemogenomics
2. HTR2A

HTR2A

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

3356

5293

P28223

5HT2A_HUMAN

5-hydroxytryptamine receptor 2A

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000366a

FANANSERIN

FC1=CC=C(C=C1)N1CCN(CCCN2C3=C4C(=CC=CC4=CC=C3)S2(=O)=O)CC1

VGIGHGMPMUCLIQ-UHFFFAOYSA-N

Antagonist

DRD4

,

HTR2A

,

HTR2C

Yes

Yes

No

Yes

EUB0000406aCl

IMIPRAMINE

CN(C)CCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2

XZZXIYZZBJDEEP-UHFFFAOYSA-N

Antagonist

DRD2

,

HRH1

,

HTR2A

,

HTR2C

Yes

Yes

No

Yes

EUB0000421a

VOLINANSERIN

COC1=CC=CC([C@H](O)C2CCN(CCC3=CC=C(F)C=C3)CC2)=C1OC

HXTGXYRHXAGCFP-OAQYLSRUSA-N

Antagonist

HTR2A

Yes

Yes

No

Yes

EUB0000422a

RITANSERIN

CC1=C(CCN2CCC(CC2)=C(C2=CC=C(F)C=C2)C2=CC=C(F)C=C2)C(=O)N2C=CSC2=N1

JUQLTPCYUFPYKE-UHFFFAOYSA-N

Antagonist

HTR2A

,

HTR2C

Yes

Yes

No

Yes

EUB0000444a

SPIRAMIDE

FC1=CC=C(OCCCN2CCC3(CC2)N(CNC3=O)C2=CC=CC=C2)C=C1

FJUKDAZEABGEIH-UHFFFAOYSA-N

Antagonist

DRD2

,

HTR2A

Yes

Yes

Yes

Yes

EUB0000456aCl

CP 809,101

ClC1=CC(COC2=NC(=CN=C2)N2CCNCC2)=CC=C1

NMUNRTCTDLORDR-UHFFFAOYSA-N

Agonist

HTR2A

,

HTR2B

,

HTR2C

Yes

Yes

No

Yes

EUB0000480a

LATREPIRDINE

CN1CCC2=C(C1)C1=CC(C)=CC=C1N2CCC1=CC=C(C)N=C1

JNODQFNWMXFMEV-UHFFFAOYSA-N

Antagonist

ADRA1A

,

ADRA2A

,

HRH1

,

HTR2A

,

HTR2C

,

HTR6

,

HTR7

Yes

Yes

Yes

Yes

EUB0000483aCl

PRUVANSERIN

FC1=CC=C(CCN2CCN(CC2)C(=O)C2=C3NC=C(C#N)C3=CC=C2)C=C1

UYGNZRVLPYZLTF-UHFFFAOYSA-N

Antagonist

HTR2A

Yes

Yes

No

Yes

EUB0000489aBDA

KETOTIFEN

CN1CCC(CC1)=C1C2=C(SC=C2)C(=O)CC2=C1C=CC=C2

YNQQEYBLVYAWNX-WLHGVMLRSA-N

Antagonist

HRH1

,

HTR2A

Yes

Yes

Yes

Yes

EUB0000491aCl

NEFAZODONE

CCC1=NN(CCCN2CCN(CC2)C2=CC=CC(Cl)=C2)C(=O)N1CCOC1=CC=CC=C1

DYCKFEBIOUQECE-UHFFFAOYSA-N

Antagonist

HTR1A

,

HTR2A

Yes

Yes

Yes

Yes