1. Chemogenomics
2. ADRA2A

ADRA2A

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

150

281

P08913

ADA2A_HUMAN

adrenoceptor alpha 2A

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000376aCl

EFAROXAN

CCC1(CC2=CC=CC=C2O1)C1=NCCN1

DWOIUCRHVWIHAH-UHFFFAOYSA-N

Antagonist

ADRA2A

Yes

Yes

No

Yes

EUB0000410aCl

Oxymetazoline

CC1=CC(=C(O)C(C)=C1CC1=NCCN1)C(C)(C)C

BEEDODBODQVSIM-UHFFFAOYSA-N

Agonist

ADRA2A

,

ADRA2C

,

HTR1B

,

HTR1D

Yes

Yes

No

Yes

EUB0000428aCl

Fluoxetine

CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1

GIYXAJPCNFJEHY-UHFFFAOYSA-N

Antagonist

ADRA2A

,

HTR2C

Yes

Yes

No

Yes

EUB0000480a

LATREPIRDINE

CN1CCC2=C(C1)C1=CC(C)=CC=C1N2CCC1=CC=C(C)N=C1

JNODQFNWMXFMEV-UHFFFAOYSA-N

Antagonist

ADRA1A

,

ADRA2A

,

HRH1

,

HTR2A

,

HTR2C

,

HTR6

,

HTR7

Yes

Yes

Yes

Yes