1. Chemogenomics
2. ADRA1A

ADRA1A

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

148

277

P35348

ADA1A_HUMAN

adrenoceptor alpha 1A

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000380aCl

NIGULDIPINE

COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCCN1CCC(CC1)(C1=CC=CC=C1)C1=CC=CC=C1

MHOSUIMBPQVOEU-UHFFFAOYSA-N

Antagonist

ADRA1A

Yes

Yes

Yes

Yes

EUB0000381a

SILODOSIN

C[C@H](CC1=CC2=C(N(CCCO)CC2)C(=C1)C(N)=O)NCCOC1=C(OCC(F)(F)F)C=CC=C1

PNCPYILNMDWPEY-QGZVFWFLSA-N

Antagonist

ADRA1A

,

ADRA1D

Yes

Yes

No

Yes

EUB0000480a

LATREPIRDINE

CN1CCC2=C(C1)C1=CC(C)=CC=C1N2CCC1=CC=C(C)N=C1

JNODQFNWMXFMEV-UHFFFAOYSA-N

Antagonist

ADRA1A

,

ADRA2A

,

HRH1

,

HTR2A

,

HTR2C

,

HTR6

,

HTR7

Yes

Yes

Yes

Yes