1. Chemogenomics
2. HRH1

HRH1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

3269

5182

P35367

HRH1_HUMAN

histamine receptor H1

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000386aBDA

DEXCHLORPHENIRAMINE

CN(C)CC[C@@H](C1=CC=C(Cl)C=C1)C1=NC=CC=C1

DBAKFASWICGISY-DASCVMRKSA-N

Antagonist

HRH1

Yes

Yes

No

Yes

EUB0000406aCl

IMIPRAMINE

CN(C)CCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2

XZZXIYZZBJDEEP-UHFFFAOYSA-N

Antagonist

DRD2

,

HRH1

,

HTR2A

,

HTR2C

Yes

Yes

No

Yes

EUB0000477aCl

FEXOFENADINE

CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1

RRJFVPUCXDGFJB-UHFFFAOYSA-N

Antagonist

HRH1

Yes

Yes

No

Yes

EUB0000480a

LATREPIRDINE

CN1CCC2=C(C1)C1=CC(C)=CC=C1N2CCC1=CC=C(C)N=C1

JNODQFNWMXFMEV-UHFFFAOYSA-N

Antagonist

ADRA1A

,

ADRA2A

,

HRH1

,

HTR2A

,

HTR2C

,

HTR6

,

HTR7

Yes

Yes

Yes

Yes

EUB0000486aCl

AZELASTINE

CN1CCCC(CC1)N1N=C(CC2=CC=C(Cl)C=C2)C2=CC=CC=C2C1=O

YEJAJYAHJQIWNU-UHFFFAOYSA-N

Antagonist

HRH1

,

HTR2B

Yes

Yes

Yes

Yes

EUB0000489aBDA

KETOTIFEN

CN1CCC(CC1)=C1C2=C(SC=C2)C(=O)CC2=C1C=CC=C2

YNQQEYBLVYAWNX-WLHGVMLRSA-N

Antagonist

HRH1

,

HTR2A

Yes

Yes

Yes

Yes

EUB0000532aBDA

CLEMASTINE

CN1CCC[C@@H]1CCO[C@](C)(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

PMGQWSIVQFOFOQ-YKVZVUFRSA-N

Antagonist

HRH1

Yes

Yes

Yes

Yes