1. Chemogenomics
2. DRD2

DRD2

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

1813

3023

P14416

DRD2_HUMAN

dopamine receptor D2

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000368aCl

REMOXIPRIDE

CCN1CCC[C@H]1CNC(=O)C1=C(OC)C(Br)=CC=C1OC

WCPXLMIPGMFZMY-MERQFXBCSA-N

Antagonist

DRD2

Yes

Yes

No

Yes

EUB0000394a

L-741,626

OC1(CCN(CC2=CNC3=CC=CC=C23)CC1)C1=CC=C(Cl)C=C1

LLBLNMUONVVVPG-UHFFFAOYSA-N

Antagonist

DRD2

,

DRD3

Yes

Yes

Yes

Yes

EUB0000406aCl

IMIPRAMINE

CN(C)CCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2

XZZXIYZZBJDEEP-UHFFFAOYSA-N

Antagonist

DRD2

,

HRH1

,

HTR2A

,

HTR2C

Yes

Yes

No

Yes

EUB0000444a

SPIRAMIDE

FC1=CC=C(OCCCN2CCC3(CC2)N(CNC3=O)C2=CC=CC=C2)C=C1

FJUKDAZEABGEIH-UHFFFAOYSA-N

Antagonist

DRD2

,

HTR2A

Yes

Yes

Yes

Yes

EUB0000493aCl

CARIPRAZINE

CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)C2=C(Cl)C(Cl)=CC=C2)CC1

GPPJWWMREQHLQT-BHQIMSFRSA-N

Antagonist

DRD2

,

DRD3

,

HTR1A

Yes

Yes

Yes

Yes