1. Chemogenomics
2. HTR1A

HTR1A

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

3350

5286

P08908

5HT1A_HUMAN

5-hydroxytryptamine receptor 1A

GPCR

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000388a

SPIROXATRINE

O=C1NCN(C2=CC=CC=C2)C11CCN(CC2COC3=C(O2)C=CC=C3)CC1

JVGBTTIJPBFLTE-UHFFFAOYSA-N

Antagonist

HTR1A

Yes

Yes

No

Yes

EUB0000445aCl

VILAZODONE

NC(=O)C1=CC2=CC(=CC=C2O1)N1CCN(CCCCC2=CNC3=CC=C(C=C23)C#N)CC1

RPZBRGFNBNQSOP-UHFFFAOYSA-N

Partial agonist

HTR1A

Yes

Yes

Yes

Yes

EUB0000491aCl

NEFAZODONE

CCC1=NN(CCCN2CCN(CC2)C2=CC=CC(Cl)=C2)C(=O)N1CCOC1=CC=CC=C1

DYCKFEBIOUQECE-UHFFFAOYSA-N

Antagonist

HTR1A

,

HTR2A

Yes

Yes

Yes

Yes

EUB0000493aCl

CARIPRAZINE

CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)C2=C(Cl)C(Cl)=CC=C2)CC1

GPPJWWMREQHLQT-BHQIMSFRSA-N

Antagonist

DRD2

,

DRD3

,

HTR1A

Yes

Yes

Yes

Yes