1. Chemogenomics
2. LRRK2

LRRK2

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

120892

18618

Q5S007

LRRK2_HUMAN

Leucine-rich repeat serine/threonine-protein kinase 2

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000622a

GSK2578215A

O=C(C1=C(OCC2=CC=CC=C2)C=CC(C3=CC(F)=NC=C3)=C1)NC4=CC=CN=C4

WCIGMFCFPXZRMQ-UHFFFAOYSA-N

LRRK2

Yes

Yes

No

Yes

EUB0000628a

XMD8-85

CN1CCN(C2=CC(OC)=C(NC3=NC=C(N(C)C(C(C=CC=C4)=C4N5C)=O)C5=N3)C=C2)CC1

DDTPGANIPBKTNU-UHFFFAOYSA-N

LRRK2

,

MAPK7

Yes

Yes

Yes

Yes

EUB0000629a

GNE-9605

CNC1=C(C(F)(F)F)C=NC(NC2=C(Cl)N([C@H]3CCN(C4COC4)C[C@@H]3F)N=C2)=N1

PUXPEQJKNAWNQA-AAEUAGOBSA-N

LRRK2

Yes

Yes

No

Yes

EUB0000648a

URMC-099

CN1CCN(CC2=CC=C(C3=CC(C(C4=CC=C(NC=C5)C5=C4)=CN6)=C6N=C3)C=C2)CC1

QKKIWEILHCXECO-UHFFFAOYSA-N

LRRK2

,

MAP3K10

,

MAP3K11

,

MAP3K9

No

Yes

Yes

Yes

EUB0000706a

MLi-2-NC

C[C@H]1CN(C[C@@H](C)O1)C2=NC=NC(C3=NN(C4=C3C=C(C=C4)OC5(C)CC5)C)=C2

YGCZGTCXWBPTDC-GASCZTMLSA-N

Neg Ctrl (MLi-2)

LRRK2

Yes

Yes

No

Yes

EUB0000715a

MLi-2

[H][C@@]1(CN(C2=NC=NC(C3=NNC4=C3C=C(OC5(CC5)C)C=C4)=C2)C[C@@](C)(O1)[H])C

ATUUNJCZCOMUKD-OKILXGFUSA-N

LRRK2

Yes

Yes

No

Yes