1. Chemogenomics
2. MAPK11

MAPK11

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

5600

6873

Q15759

MK11_HUMAN

Mitogen-activated protein kinase 11

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000132b

SR318

Nc1c(C(=O)NCc2ccc(C(=O)NCCCC3CCCCC3)cc2)cnn1-c1ccccc1

HXNUFFCHRIWTRZ-UHFFFAOYSA-N

MAPK11

,

MAPK14

Yes

Yes

No

Yes

EUB0000711a

SR321

FC(F)(F)C1=C(C=NN1C2=CC=CC=C2)C(NCC3=CC=C(C=C3)C(NCCCC4CCCCC4)=O)=O

HMPXSYOFBMBHDF-UHFFFAOYSA-N

Neg Ctrl (SR318)

MAPK11

,

MAPK14

Yes

Yes

No

Yes

EUB0000712a

SR-302

CS(N1CCCC(NC([C@@H](NC(C2=CC=C(C=C2)CNC(C3=CN=C4C=CC=CN34)=O)=O)CCC5CCCCC5)=O)C1)(=O)=O

WGMNFJAFXXXRLZ-GEVKEYJPSA-N

DDR1

,

DDR2

,

MAPK11

,

MAPK14

Yes

Yes

Yes

Yes

EUB0000717a

L-Skepinone

C1Cc2cc(ccc2C(c2cc(ccc12)OC[C@@H](CO)O)=O)Nc1ccc(cc1F)F

HXMGCTFLLWPVFM-GOSISDBHSA-N

MAPK11

,

MAPK14

Yes

Yes

No

Yes

EUB0000718a

FS-694

C1Cc2cc(ccc2C(c2cc(ccc12)C(NCCN1CCOCC1)=O)=O)Nc1ccc(c(c1)NC(c1ccccc1)=O)F

JWZSSEWMVYKYKW-UHFFFAOYSA-N

MAPK11

,

MAPK14

Yes

Yes

No

Yes