1. Chemogenomics
2. DDR2

DDR2

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

4921

2731

Q16832

DDR2_HUMAN

Discoidin domain-containing receptor 2

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000005b

DDR-TRK-1 (D2202-1)

Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)CN(c3cncnc3)C[C@@H]4C)cc(C(F)(F)F)c2)cn1

CMJJZRAAQMUAFH-INIZCTEOSA-N

DDR1

,

DDR2

,

NTRK1

,

NTRK2

,

NTRK3

Yes

Yes

No

Yes

EUB0000156b

DDR-TRK-1N (380079)

CN1CCN(Cc2cc(NC(=O)c3ccc4c(c3)CN(c3ccccc3)CC4)cc(C(F)(F)F)c2)CC1

FWKRCZKMCJOFNG-UHFFFAOYSA-N

Neg Ctrl (DDR-TRK-1 (D2202-1))

DDR1

,

DDR2

,

NTRK1

,

NTRK2

,

NTRK3

Yes

Yes

No

No

EUB0000703a

BAY-309

O=C(C1=CC=CC(S(F)(F)(F)(F)F)=C1)NC2=CC(C)=CC(N3C=CN(C3=C4)N=C4C5=CN=CC=C5)=C2

MOONEVNPHKFNGV-UHFFFAOYSA-N

Neg Ctrl (BAY-826)

DDR1

,

DDR2

,

TEK

,

TIE1

Yes

Yes

No

Yes

EUB0000712a

SR-302

CS(N1CCCC(NC([C@@H](NC(C2=CC=C(C=C2)CNC(C3=CN=C4C=CC=CN34)=O)=O)CCC5CCCCC5)=O)C1)(=O)=O

WGMNFJAFXXXRLZ-GEVKEYJPSA-N

DDR1

,

DDR2

,

MAPK11

,

MAPK14

Yes

Yes

Yes

Yes

EUB0000713a

BAY-826

N#CC1=CC(S(F)(F)(F)(F)F)=CC(C(NC2=C(C)C=C(C)C(N3C=CN(C3=C4)N=C4C5=CN=CC=C5)=C2)=O)=C1

MPASHPJAIUOWCK-UHFFFAOYSA-N

DDR1

,

DDR2

,

TEK

,

TIE1

Yes

Yes

No

Yes