1. Chemogenomics
2. TIE1

TIE1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

7075

11809

P35590

TIE1_HUMAN

Tyrosine-protein kinase receptor Tie-1

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000703a

BAY-309

O=C(C1=CC=CC(S(F)(F)(F)(F)F)=C1)NC2=CC(C)=CC(N3C=CN(C3=C4)N=C4C5=CN=CC=C5)=C2

MOONEVNPHKFNGV-UHFFFAOYSA-N

Neg Ctrl (BAY-826)

DDR1

,

DDR2

,

TEK

,

TIE1

Yes

Yes

No

Yes

EUB0000713a

BAY-826

N#CC1=CC(S(F)(F)(F)(F)F)=CC(C(NC2=C(C)C=C(C)C(N3C=CN(C3=C4)N=C4C5=CN=CC=C5)=C2)=O)=C1

MPASHPJAIUOWCK-UHFFFAOYSA-N

DDR1

,

DDR2

,

TEK

,

TIE1

Yes

Yes

No

Yes