1. Chemogenomics
2. NTRK3

NTRK3

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

4916

8033

Q16288

NTRK3_HUMAN

NT-3 growth factor receptor

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000005b

DDR-TRK-1 (D2202-1)

Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)CN(c3cncnc3)C[C@@H]4C)cc(C(F)(F)F)c2)cn1

CMJJZRAAQMUAFH-INIZCTEOSA-N

DDR1

,

DDR2

,

NTRK1

,

NTRK2

,

NTRK3

Yes

Yes

No

Yes

EUB0000136b

GNF-5837

Cc1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1

YYDUWLSETXNJJT-MTJSOVHGSA-N

NTRK1

,

NTRK2

,

NTRK3

Yes

Yes

No

Yes

EUB0000156b

DDR-TRK-1N (380079)

CN1CCN(Cc2cc(NC(=O)c3ccc4c(c3)CN(c3ccccc3)CC4)cc(C(F)(F)F)c2)CC1

FWKRCZKMCJOFNG-UHFFFAOYSA-N

Neg Ctrl (DDR-TRK-1 (D2202-1))

DDR1

,

DDR2

,

NTRK1

,

NTRK2

,

NTRK3

Yes

Yes

No

No

EUB0000640a

LOXO-195

O=C(N[C@H](C)CCC1=NC=C(F)C=C1[C@]2([H])N3CCC2)C4=C5N(N=C4)C=CC3=N5

OEBIHOVSAMBXIB-SJKOYZFVSA-N

inhibitor

NTRK1

,

NTRK2

,

NTRK3

No

Yes

No

Yes