1. Chemogenomics
2. NR1H3

NR1H3

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

10062

7966

Q13133

NR1H3_HUMAN

liver X receptor alpha

Nuclear receptor

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000040b

T0901317

C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O

SGIWFELWJPNFDH-UHFFFAOYSA-N

NR1H2

,

NR1H3

,

NR1H4

,

NR1I2

,

RORC

Yes

Yes

No

Yes

EUB0000183b

GSK2033

CC1=CC(=C(C(=C1)C)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CC(=CC=C3)S(=O)(=O)C)CC4=CC=C(O4)C(F)(F)F)C

PSOXOVKYGWBTPB-UHFFFAOYSA-N

NR1H2

,

NR1H3

Yes

Yes

Yes

Yes

EUB0000572aCl

GW3965

C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl

NMPUWJFHNOUNQU-UHFFFAOYSA-N

NR1H2

,

NR1H3

Yes

Yes

No

Yes