1. Chemogenomics
2. NR1H4

NR1H4

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

9971

7967

Q96RI1

NR1H4_HUMAN

farnesoid X receptor

Nuclear receptor

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000040b

T0901317

C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O

SGIWFELWJPNFDH-UHFFFAOYSA-N

NR1H2

,

NR1H3

,

NR1H4

,

NR1I2

,

RORC

Yes

Yes

No

Yes

EUB0000182b

fexaramine

CN(C)C1=CC=C(C=C1)C2=CC=C(C=C2)CN(C3=CC=CC(=C3)/C=C/C(=O)OC)C(=O)C4CCCCC4

VLQTUNDJHLEFEQ-KGENOOAVSA-N

NR1H4

Yes

Yes

No

Yes

EUB0000184b

GW4064

CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)/C=C/C4=CC(=CC=C4)C(=O)O)Cl

BYTNEISLBIENSA-MDZDMXLPSA-N

NR1H4

Yes

Yes

No

Yes

EUB0000573a

xl335

CC(C)OC(=O)C1=CN(CC(C2=C1NC3=CC=CC=C32)(C)C)C(=O)C4=CC(=C(C=C4)F)F

INASOKQDNHHMRE-UHFFFAOYSA-N

NR1H4

Yes

Yes

No

Yes