1. Chemogenomics
2. TTK

TTK

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

7272

12401

P33981

TTK_HUMAN

Dual specificity protein kinase TTK

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000608a

Mps1-IN-2

OC1CCN(C2=CC(OCC)=C(NC3=NC=C(N(C)C(CCN4C5CCCC5)=O)C4=N3)C=C2)CC1

WELBJLUKWAJOQV-UHFFFAOYSA-N

PLK1

,

TTK

Yes

Yes

No

No

EUB0000609a

Mps1-IN-1

COC1=C(NC2=CC(NC3=CC=CC=C3S(C(C)C)(=O)=O)=C(C=CN4)C4=N2)C=CC(N5CCC(O)CC5)=C1

NMJMRSQTDLRCRQ-UHFFFAOYSA-N

TTK

Yes

Yes

No

No

EUB0000612a

NMS-P715

O=C(C1=NN(C)C2=C1CCC3=C2N=C(NC4=CC=C(C(NC5CCN(CC5)C)=O)C=C4OC(F)(F)F)N=C3)NC6=C(CC)C=CC=C6CC

JFOAJUGFHDCBJJ-UHFFFAOYSA-N

TTK

No

Yes

Yes

No

EUB0000633a

MPS1/TTK Inhibitor

CN(N=C1C(NC2=C(CC)C=CC=C2CC)=O)C3=C1CCC4=C3N=C(NC5=C(OC)C=C(N6CCN(C)CC6)C=C5)N=C4

DHKBTAOKHPQHKT-UHFFFAOYSA-N

TTK

No

Yes

No

No

EUB0000634a

BAY 12-17389

CC1=C(C=CC(=C1)C2=CN=C3N2N=C(C=C3NCCC(F)(F)F)OC4=C(C(=C(C=C4)OC)F)F)C(=O)NC5CC5

WNEILUNVMHVMPH-UHFFFAOYSA-N

TTK

Yes

Yes

No

No

EUB0000642a

CC-671

CC1=NC2=C(O1)C=C(C=C2)C3=CNC4=C3C(=NC(=N4)NC5=C(C=C(C=C5)C(=O)NC)OC)OC6CCCC6

CWJLAVRXVFHDSJ-UHFFFAOYSA-N

CLK2

,

TTK

Yes

Yes

No

No