1. Chemogenomics
2. PLK1

PLK1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

5347

9077

P53350

PLK1_HUMAN

Serine/threonine-protein kinase PLK1

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000169b

BI-2536

CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1

XQVVPGYIWAGRNI-JOCHJYFZSA-N

BRD4@BD1

,

PLK1

Yes

Yes

No

Yes

EUB0000603a

GSK461364

CN1CCN(CC1)CC2=CC3=C(C=C2)N=CN3C4=CC(O[C@H](C)C5=C(C(F)(F)F)C=CC=C5)=C(S4)C(N)=O

ZHJGWYRLJUCMRT-QGZVFWFLSA-N

PLK1

Yes

Yes

Yes

Yes

EUB0000605a

Adavosertib

CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O

BKWJAKQVGHWELA-UHFFFAOYSA-N

PLK1

,

WEE1

,

WEE2

Yes

Yes

No

No

EUB0000608a

Mps1-IN-2

OC1CCN(C2=CC(OCC)=C(NC3=NC=C(N(C)C(CCN4C5CCCC5)=O)C4=N3)C=C2)CC1

WELBJLUKWAJOQV-UHFFFAOYSA-N

PLK1

,

TTK

Yes

Yes

No

No

EUB0000669a

Volasertib

CC[C@@H]1C(N(C)C2=CN=C(NC3=C(OC)C=C(C(N[C@@H]4CC[C@@H](N5CCN(CC6CC6)CC5)CC4)=O)C=C3)N=C2N1C(C)C)=O

SXNJFOWDRLKDSF-STROYTFGSA-N

PLK1

,

PLK2

,

PLK3

Yes

Yes

No

Yes

EUB0000677a

NMS-1286937

CN1CCN(C2=CC=C(OC(F)(F)F)C(NC3=NC=C(CCC4=C5N(CCO)N=C4C(N)=O)C5=N3)=C2)CC1

QHLVBNKYJGBCQJ-UHFFFAOYSA-N

PLK1

Yes

Yes

Yes

Yes

EUB0000698a

GW843682X

COC1=C(OC)C=C(N=CN2C3=CC(OCC4=CC=CC=C4C(F)(F)F)=C(C(N)=O)S3)C2=C1

JSKUWFIZUALZLX-UHFFFAOYSA-N

PLK1

,

PLK3

Yes

Yes

Yes

Yes