1. Chemogenomics
  2. ALK

ALK

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family
238
427
Q9UM73
ALK_HUMAN
ALK tyrosine kinase receptor
Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available
EUB0000176b
Brigatinib (AP-26113)
Chemical structure of compound Brigatinib (AP-26113)
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1
AILRADAXUVEEIR-UHFFFAOYSA-N
ALK
,
FLT3
,
IGF1R
,
ROS1
Yes
Yes
No
Yes
EUB0000635a
ALK-IN-1
Chemical structure of compound ALK-IN-1
CN(C)C1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)Cl)OC
OVDSPTSBIQCAIN-UHFFFAOYSA-N
ALK
Yes
Yes
Yes
Yes
EUB0000688a
ASP3026
Chemical structure of compound ASP3026
CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=N2)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC
MGGBYMDAPCCKCT-UHFFFAOYSA-N
ALK
,
ROS1
,
TNK2
Yes
Yes
No
Yes
EUB0000690a
Lorlatinib
Chemical structure of compound Lorlatinib
FC1=CC=C(C(N(C)CC2=NN(C)C(C#N)=C32)=O)C([C@@H](C)OC4=C(N)N=CC3=C4)=C1
IIXWYSCJSQVBQM-LLVKDONJSA-N
ALK
,
ROS1
No
Yes
No
Yes