1. Chemogenomics
2. ROS1

ROS1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

6098

10261

P08922

ROS1_HUMAN

Proto-oncogene tyrosine-protein kinase ROS

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000176b

Brigatinib (AP-26113)

COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1

AILRADAXUVEEIR-UHFFFAOYSA-N

ALK

,

FLT3

,

IGF1R

,

ROS1

Yes

Yes

No

Yes

EUB0000688a

ASP3026

CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=N2)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC

MGGBYMDAPCCKCT-UHFFFAOYSA-N

ALK

,

ROS1

,

TNK2

Yes

Yes

No

Yes

EUB0000690a

Lorlatinib

FC1=CC=C(C(N(C)CC2=NN(C)C(C#N)=C32)=O)C([C@@H](C)OC4=C(N)N=CC3=C4)=C1

IIXWYSCJSQVBQM-LLVKDONJSA-N

ALK

,

ROS1

No

Yes

No

Yes