1. Chemogenomics
2. JAK1@kinase 1

JAK1@kinase 1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

3716

6190

P23458

JAK1_HUMAN

Tyrosine-protein kinase JAK1

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000286bCit

Tofacitinib

C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12.O=C(O)CC(O)(CC(=O)O)C(=O)O

SYIKUFDOYJFGBQ-YLAFAASESA-N

JAK1@kinase 1

,

JAK2@kinase 1

,

JAK3@kinase 1

Yes

Yes

No

Yes

EUB0000626a

Filgotinib

C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5

RIJLVEAXPNLDTC-UHFFFAOYSA-N

JAK1@kinase 1

,

JAK2@kinase 1

Yes

Yes

No

Yes

EUB0000644a

Upadacitinib

CC[C@H](CN(C(NCC(F)(F)F)=O)C1)[C@@]1([H])C2=CN=C3C=NC4=C(C=CN4)N32

WYQFJHHDOKWSHR-MNOVXSKESA-N

JAK1@kinase 1

,

JAK2@kinase 1

No

Yes

No

Yes

EUB0000673a

Momelotinib

O=C(NCC#N)C(C=C1)=CC=C1C2=NC(NC(C=C3)=CC=C3N4CCOCC4)=NC=C2

ZVHNDZWQTBEVRY-UHFFFAOYSA-N

JAK1@kinase 1

,

JAK2@kinase 1

Yes

Yes

Yes

Yes