1. Chemogenomics
2. JAK2@kinase 1

JAK2@kinase 1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

3717

6192

O60674

JAK2_HUMAN

Tyrosine-protein kinase JAK2

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000286bCit

Tofacitinib

C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12.O=C(O)CC(O)(CC(=O)O)C(=O)O

SYIKUFDOYJFGBQ-YLAFAASESA-N

JAK1@kinase 1

,

JAK2@kinase 1

,

JAK3@kinase 1

Yes

Yes

No

Yes

EUB0000626a

Filgotinib

C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5

RIJLVEAXPNLDTC-UHFFFAOYSA-N

JAK1@kinase 1

,

JAK2@kinase 1

Yes

Yes

No

Yes

EUB0000644a

Upadacitinib

CC[C@H](CN(C(NCC(F)(F)F)=O)C1)[C@@]1([H])C2=CN=C3C=NC4=C(C=CN4)N32

WYQFJHHDOKWSHR-MNOVXSKESA-N

JAK1@kinase 1

,

JAK2@kinase 1

No

Yes

No

Yes

EUB0000673a

Momelotinib

O=C(NCC#N)C(C=C1)=CC=C1C2=NC(NC(C=C3)=CC=C3N4CCOCC4)=NC=C2

ZVHNDZWQTBEVRY-UHFFFAOYSA-N

JAK1@kinase 1

,

JAK2@kinase 1

Yes

Yes

Yes

Yes

EUB0000681a

Pacritinib

C12=C(OCCN3CCCC3)C=CC(/N=C4N=CC=C(C5=CC=CC(COC/C=C/COC2)=C5)N/4)=C1

HWXVIOGONBBTBY-ONEGZZNKSA-N

FLT3

,

JAK2@kinase 1

,

TYK2@kinase 1

Yes

Yes

Yes

Yes

EUB0000682a

XL019

O=C([C@H]1NCCC1)NC(C=C2)=CC=C2C3=CC=NC(NC(C=C4)=CC=C4N5CCOCC5)=N3

ISOCDPQFIXDIMS-QHCPKHFHSA-N

JAK2@kinase 1

Yes

Yes

Yes

Yes