1. Chemogenomics
2. JAK3@kinase 1

JAK3@kinase 1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

3718

6193

P52333

JAK3_HUMAN

Tyrosine-protein kinase JAK3

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000006b

FM-381

CN(C)C(=O)/C(C#N)=C/c1ccc(-c2nc3cnc4[nH]ccc4c3n2C2CCCCC2)o1

GJMZWYLOARVASY-NTCAYCPXSA-N

JAK3@kinase 1

Yes

Yes

Yes

Yes

EUB0000007b

FM-479

CN(C)C(=O)/C(C#N)=C/c1ccc(-c2nc3cnc4c(ccn4C)c3n2C2CCCCC2)o1

RPIGHLXKDWUGDT-DTQAZKPQSA-N

Neg Ctrl (FM-381)

JAK3@kinase 1

Yes

Yes

No

No

EUB0000286bCit

Tofacitinib

C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12.O=C(O)CC(O)(CC(=O)O)C(=O)O

SYIKUFDOYJFGBQ-YLAFAASESA-N

JAK1@kinase 1

,

JAK2@kinase 1

,

JAK3@kinase 1

Yes

Yes

No

Yes