1. Chemogenomics
2. ABL1

ABL1

NCBI gene ID HGNC ID UniProt ID SwissProt ID Description Protein family

25

76

P00519

ABL1_HUMAN

Tyrosine-protein kinase ABL1

Protein Kinase

Compounds

Compound EUbOPEN ID Compound name Compound image SMILES / InChIKey Mode of action Main target Chem QC data available Incucyte cytotox data available Multiplex data available Other annotation data available

EUB0000020bCl

NG 25 (hydrochloride hydrate)

CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(OC4=CC=NC5=C4C=CN5)=C(C)C=C3)=O)C=C2)CC1.Cl.Cl.Cl.O

MTCWJLFLTFRXLX-UHFFFAOYSA-N

ABL1

,

CSK

,

FER

,

LYN

,

MAP3K7

,

MAP4K2

,

MAPK14

,

SRC

Yes

Yes

No

No

EUB0000593a

Nilotinib

Cc1ncn(c1)c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)c3cccnc3)c2)cc(c1)C(F)(F)F

HHZIURLSWUIHRB-UHFFFAOYSA-N

ABL1

,

ABL2

Yes

Yes

Yes

Yes

EUB0000615a

Rebastinib

CC(C)(C1=NN(C2=CC=C3C(C=CC=N3)=C2)C(N([H])C(N(C4=CC=C(C=C4F)OC5=CC(C(N(C)[H])=O)=NC=C5)[H])=O)=C1)C

WVXNSAVVKYZVOE-UHFFFAOYSA-N

ABL1

Yes

Yes

No

Yes

EUB0000875a

GNF2

NC(C1=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=CC=C1)=O

WEVYNIUIFUYDGI-UHFFFAOYSA-N

allosteric

ABL1

,

ABL2

Yes

Yes

No

Yes